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Two waves of de novo methylation during mouse germ cell development

During development, mammalian germ cells reprogram their epigenomes via a genome-wide erasure and de novo rewriting of DNA methylation marks. We know little of how methylation patterns are specifically determined. The piRNA pathway is thought to target the bulk of retrotransposon methylation. Here w...

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Detalles Bibliográficos
Autores principales: Molaro, Antoine, Falciatori, Ilaria, Hodges, Emily, Aravin, Alexei A., Marran, Krista, Rafii, Shahin, McCombie, W. Richard, Smith, Andrew D., Hannon, Gregory J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102761/
https://www.ncbi.nlm.nih.gov/pubmed/25030694
http://dx.doi.org/10.1101/gad.244350.114