Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5′-to-3′ exonuclease Xrn1

In eukaryotes and archaea, tRNA splicing generates free intron molecules. Although ∼600,000 introns are produced per generation in yeast, they are barely detectable in cells, indicating efficient turnover of introns. Through a genome-wide search for genes involved in tRNA biology in yeast, we uncove...

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Detalles Bibliográficos
Autores principales: Wu, Jingyan, Hopper, Anita K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102763/
https://www.ncbi.nlm.nih.gov/pubmed/25030695
http://dx.doi.org/10.1101/gad.244673.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102763/
https://www.ncbi.nlm.nih.gov/pubmed/25030695
http://dx.doi.org/10.1101/gad.244673.114

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