Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors

PARP inhibitors hold promise as a novel class of targeted anticancer drugs. However, their true mechanism of action is still not well understood following recent reports that show marked differences in cellular effects. Here, we demonstrate that three PARP drug candidates, namely, rucaparib, velipar...

Descripción completa

Detalles Bibliográficos
Autores principales: Antolín, Albert A., Mestres, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102788/
https://www.ncbi.nlm.nih.gov/pubmed/24632590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102788/
https://www.ncbi.nlm.nih.gov/pubmed/24632590

Ejemplares similares