Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity

Hsp70 chaperone is known to stimulate anti-tumour immunity in a variety of cancer models. Here we demonstrated that the addition of purified recombinant Hsp70 to the culture medium facilitated cancer cell cytolysis by lymphocytes. Importantly, exogenous Hsp70 triggered secretion of the intracellular...

Descripción completa

Detalles Bibliográficos
Autores principales: Shevtsov, Maxim A., Komarova, Elena Y., Meshalkina, Darya A., Bychkova, Natalia V., Aksenov, Nikolai D., Abkin, Sergey V., Margulis, Boris A., Guzhova, Irina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102795/
https://www.ncbi.nlm.nih.gov/pubmed/24797019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102795/
https://www.ncbi.nlm.nih.gov/pubmed/24797019

Ejemplares similares