Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy

Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer. We have developed small molecule inhibitors against APE1 repair nuclease activity. In the current study we explored a synth...

Descripción completa

Detalles Bibliográficos
Autores principales: Abbotts, Rachel, Jewell, Rosalyn, Nsengimana, Jérémie, Maloney, David J, Simeonov, Anton, Seedhouse, Claire, Elliott, Faye, Laye, Jon, Walker, Christy, Jadhav, Ajit, Grabowska, Anna, Ball, Graham, Patel, Poulam M, Newton-Bishop, Julia, Wilson, David M, Madhusudan, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102809/
https://www.ncbi.nlm.nih.gov/pubmed/24830350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102809/
https://www.ncbi.nlm.nih.gov/pubmed/24830350

Ejemplares similares