NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery

Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesi...

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Detalles Bibliográficos
Autores principales: Barry, Gerald, Varela, Mariana, Ratinier, Maxime, Blomström, Anne-Lie, Caporale, Marco, Seehusen, Frauke, Hahn, Kerstin, Schnettler, Esther, Baumgärtner, Wolfgang, Kohl, Alain, Palmarini, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2014
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103064/
https://www.ncbi.nlm.nih.gov/pubmed/24828331
http://dx.doi.org/10.1099/vir.0.065425-0
Descripción
Sumario:Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways.

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