NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery

Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesi...

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Autores principales: Barry, Gerald, Varela, Mariana, Ratinier, Maxime, Blomström, Anne-Lie, Caporale, Marco, Seehusen, Frauke, Hahn, Kerstin, Schnettler, Esther, Baumgärtner, Wolfgang, Kohl, Alain, Palmarini, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2014
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103064/
https://www.ncbi.nlm.nih.gov/pubmed/24828331
http://dx.doi.org/10.1099/vir.0.065425-0
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author Barry, Gerald
Varela, Mariana
Ratinier, Maxime
Blomström, Anne-Lie
Caporale, Marco
Seehusen, Frauke
Hahn, Kerstin
Schnettler, Esther
Baumgärtner, Wolfgang
Kohl, Alain
Palmarini, Massimo
author_facet Barry, Gerald
Varela, Mariana
Ratinier, Maxime
Blomström, Anne-Lie
Caporale, Marco
Seehusen, Frauke
Hahn, Kerstin
Schnettler, Esther
Baumgärtner, Wolfgang
Kohl, Alain
Palmarini, Massimo
author_sort Barry, Gerald
collection PubMed
description Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways.
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spelling pubmed-41030642014-08-15 NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery Barry, Gerald Varela, Mariana Ratinier, Maxime Blomström, Anne-Lie Caporale, Marco Seehusen, Frauke Hahn, Kerstin Schnettler, Esther Baumgärtner, Wolfgang Kohl, Alain Palmarini, Massimo J Gen Virol Animal Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways. Society for General Microbiology 2014-08 /pmc/articles/PMC4103064/ /pubmed/24828331 http://dx.doi.org/10.1099/vir.0.065425-0 Text en © 2014 The Authors http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Animal
Barry, Gerald
Varela, Mariana
Ratinier, Maxime
Blomström, Anne-Lie
Caporale, Marco
Seehusen, Frauke
Hahn, Kerstin
Schnettler, Esther
Baumgärtner, Wolfgang
Kohl, Alain
Palmarini, Massimo
NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
title NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
title_full NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
title_fullStr NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
title_full_unstemmed NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
title_short NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
title_sort nss protein of schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery
topic Animal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103064/
https://www.ncbi.nlm.nih.gov/pubmed/24828331
http://dx.doi.org/10.1099/vir.0.065425-0
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