Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones

Expression or introduction of the neuropeptide substance-P (SP; encoded by the TAC1 gene in humans and Tac1 in rodents) in the amygdala induces anxiety related behaviour in rodents. In addition, pharmacological antagonism of the main receptor of SP in humans; NK1, is anxiolytic. In the current study...

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Detalles Bibliográficos
Autores principales: Hay, Colin W., Shanley, Lynne, Davidson, Scott, Cowie, Philip, Lear, Marissa, McGuffin, Peter, Riedel, Gernot, McEwan, Iain J., MacKenzie, Alasdair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103484/
https://www.ncbi.nlm.nih.gov/pubmed/25001955
http://dx.doi.org/10.1016/j.psyneuen.2014.04.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103484/
https://www.ncbi.nlm.nih.gov/pubmed/25001955
http://dx.doi.org/10.1016/j.psyneuen.2014.04.017

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