P-Glycoprotein Mediated Efflux Limits the Transport of the Novel Anti-Parkinson's Disease Candidate Drug FLZ across the Physiological and PD Pathological In Vitro BBB Models

FLZ, a novel anti-Parkinson's disease (PD) candidate drug, has shown poor blood-brain barrier (BBB) penetration based on the pharmacokinetic study using rat brain. P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two important transporters obstructing substrates entry into...

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Detalles Bibliográficos
Autores principales: Liu, Qian, Hou, Jinfeng, Chen, Xiaoguang, Liu, Gengtao, Zhang, Dan, Sun, Hua, Zhang, Jinlan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103815/
https://www.ncbi.nlm.nih.gov/pubmed/25036090
http://dx.doi.org/10.1371/journal.pone.0102442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103815/
https://www.ncbi.nlm.nih.gov/pubmed/25036090
http://dx.doi.org/10.1371/journal.pone.0102442

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