Cargando…

Computational Investigation of Locked Nucleic Acid (LNA) Nucleotides in the Active Sites of DNA Polymerases by Molecular Docking Simulations

Aptamers constitute a potential class of therapeutic molecules typically selected from a large pool of oligonucleotides against a specific target. With a scope of developing unique shorter aptamers with very high biostability and affinity, locked nucleic acid (LNA) nucleotides have been investigated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poongavanam, Vasanthanathan, Madala, Praveen K., Højland, Torben, Veedu, Rakesh N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103837/ https://www.ncbi.nlm.nih.gov/pubmed/25036012 http://dx.doi.org/10.1371/journal.pone.0102126

Ejemplares similares

Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides
por: Højland, Torben, et al.
Publicado: (2012)

NMR solution structures of LNA (locked nucleic acid) modified quadruplexes
por: Nielsen, Jakob T., et al.
Publicado: (2006)

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
por: Elmén, Joacim, et al.
Publicado: (2005)

Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)
por: Kumar, Pawan, et al.
Publicado: (2014)

Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics
por: Kauppinen, Sakari, et al.
Publicado: (2005)

Position-dependent effects of locked nucleic acid (LNA) on DNA sequencing and PCR primers
por: Levin, Joshua D., et al.
Publicado: (2006)

Efficient Reverse Transcription Using Locked Nucleic Acid Nucleotides towards the Evolution of Nuclease Resistant RNA Aptamers
por: Crouzier, Lucile, et al.
Publicado: (2012)

Insights into structure, dynamics and hydration of locked nucleic acid (LNA) strand-based duplexes from molecular dynamics simulations
por: Pande, Vineet, et al.
Publicado: (2008)

Amplification and Re-Generation of LNA-Modified Libraries
por: Doessing, Holger, et al.
Publicado: (2012)

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA
por: Kumar, Pawan, et al.
Publicado: (2017)

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications
por: Thorpe, Cameron, et al.
Publicado: (2019)

An Investigation into the Potential of Targeting Escherichia coli rne mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy
por: Goddard, Layla R., et al.
Publicado: (2021)

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA
por: Moreno, Pedro M. D., et al.
Publicado: (2013)

Application of Locked Nucleic Acid (LNA) Primer and PCR Clamping by LNA Oligonucleotide to Enhance the Amplification of Internal Transcribed Spacer (ITS) Regions in Investigating the Community Structures of Plant–Associated Fungi
por: Ikenaga, Makoto, et al.
Publicado: (2016)

Characteristics and prognostic analysis of patients with detected KRAS mutations in resected lung adenocarcinomas by peptide nucleic acid-locked nucleic acid polymerase chain reaction (PNA-LNA PCR) clamp method
por: Hashimoto, Tatsuya, et al.
Publicado: (2023)

Discovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach
por: Prepens, Sandra, et al.
Publicado: (2007)

Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection
por: Zhang, Y, et al.
Publicado: (2011)

A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo
por: Gupta, Nidhi, et al.
Publicado: (2010)

Novel locked nucleic acid (LNA)-based probe for the rapid identification of Chlamydia suis using real-time PCR
por: Lis, Paweł, et al.
Publicado: (2014)

In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer
por: Torres, Anna, et al.
Publicado: (2016)

Hybridization-Based Detection of Helicobacter pylori at Human Body Temperature Using Advanced Locked Nucleic Acid (LNA) Probes
por: Fontenete, Sílvia, et al.
Publicado: (2013)

Development of an Efficient G‐Quadruplex‐Stabilised Thrombin‐Binding Aptamer Containing a Three‐Carbon Spacer Molecule
por: Aaldering, Lukas J., et al.
Publicado: (2017)

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold
por: Marušič, Maja, et al.
Publicado: (2013)

Erratum to: In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer
por: Torres, Anna, et al.
Publicado: (2016)

Alpha-l-Locked Nucleic Acid-Modified Antisense Oligonucleotides Induce Efficient Splice Modulation In Vitro
por: Raguraman, Prithi, et al.
Publicado: (2020)

Locked Nucleic Acid Flow Cytometry-fluorescence in situ Hybridization (LNA flow-FISH): a Method for Bacterial Small RNA Detection
por: Robertson, Kelly L., et al.
Publicado: (2012)

In Vitro and In Vivo Activity of a Novel Locked Nucleic Acid (LNA)-Inhibitor-miR-221 against Multiple Myeloma Cells
por: Di Martino, Maria Teresa, et al.
Publicado: (2014)

Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes
por: Geny, Sylvain, et al.
Publicado: (2016)

Virtual Screening Models for Prediction of HIV-1 RT Associated RNase H Inhibition
por: Poongavanam, Vasanthanathan, et al.
Publicado: (2013)

Optimizing locked nucleic acid/2’-O-methyl-RNA fluorescence in situ hybridization (LNA/2’OMe-FISH) procedure for bacterial detection
por: Azevedo, Andreia S., et al.
Publicado: (2019)

Rational Design of Short Locked Nucleic Acid-Modified 2′-O-Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro
por: Le, Bao T., et al.
Publicado: (2017)

Application of Locked Nucleic Acid (LNA) Oligonucleotide–PCR Clamping Technique to Selectively PCR Amplify the SSU rRNA Genes of Bacteria in Investigating the Plant-Associated Community Structures
por: Ikenaga, Makoto, et al.
Publicado: (2014)

Inhibitor Ranking through QM Based Chelation Calculations for Virtual Screening of HIV-1 RNase H Inhibition
por: Poongavanam, Vasanthanathan, et al.
Publicado: (2014)

Computational Modeling Explains the Multi Sterol Ligand Specificity of the N-Terminal Domain of Niemann–Pick C1-Like 1 Protein
por: Poongavanam, Vasanthanathan, et al.
Publicado: (2019)

Simulation Reveals the Chameleonic Behavior of Macrocycles
por: Sethio, Daniel, et al.
Publicado: (2022)

Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry
por: Förster, Charlotte, et al.
Publicado: (2012)

Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors
por: Poongavanam, Vasanthanathan, et al.
Publicado: (2012)

Ligand and Structure-Based Classification Models for Prediction of P-Glycoprotein Inhibitors
por: Klepsch, Freya, et al.
Publicado: (2013)

Macrocycles in Drug Discovery—Learning from the Past for the Future
por: Garcia Jimenez, Diego, et al.
Publicado: (2023)

A Locked Nucleic Acid (LNA)-Based Real-Time PCR Assay for the Rapid Detection of Multiple Bacterial Antibiotic Resistance Genes Directly from Positive Blood Culture
por: Zhu, Lingxiang, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pk0nbuprkmtqbghs51ro6kk562