Design of a colicin E7 based chimeric zinc-finger nuclease

Colicin E7 is a natural bacterial toxin. Its nuclease domain (NColE7) enters the target cell and kills it by digesting the nucleic acids. The HNH-motif as the catalytic centre of NColE7 at the C-terminus requires the positively charged N-terminal loop for the nuclease activity—offering opportunities...

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Detalles Bibliográficos
Autores principales: Németh, Eszter, Schilli, Gabriella K., Nagy, Gábor, Hasenhindl, Christoph, Gyurcsik, Béla, Oostenbrink, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104000/
https://www.ncbi.nlm.nih.gov/pubmed/24952471
http://dx.doi.org/10.1007/s10822-014-9765-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104000/
https://www.ncbi.nlm.nih.gov/pubmed/24952471
http://dx.doi.org/10.1007/s10822-014-9765-8

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