Relative adrenal insufficiency in mice deficient in 5α-reductase 1

Patients with critical illness or hepatic failure exhibit impaired cortisol responses to ACTH, a phenomenon known as ‘relative adrenal insufficiency’. A putative mechanism is that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases type 1 and type 2 and 5β-reductase, resul...

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Detalles Bibliográficos
Autores principales: Livingstone, Dawn E W, Di Rollo, Emma M, Yang, Chenjing, Codrington, Lucy E, Mathews, John A, Kara, Madina, Hughes, Katherine A, Kenyon, Christopher J, Walker, Brian R, Andrew, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104038/
https://www.ncbi.nlm.nih.gov/pubmed/24872577
http://dx.doi.org/10.1530/JOE-13-0563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104038/
https://www.ncbi.nlm.nih.gov/pubmed/24872577
http://dx.doi.org/10.1530/JOE-13-0563

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