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Relative adrenal insufficiency in mice deficient in 5α-reductase 1

Patients with critical illness or hepatic failure exhibit impaired cortisol responses to ACTH, a phenomenon known as ‘relative adrenal insufficiency’. A putative mechanism is that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases type 1 and type 2 and 5β-reductase, resul...

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Detalles Bibliográficos
Autores principales:	Livingstone, Dawn E W, Di Rollo, Emma M, Yang, Chenjing, Codrington, Lucy E, Mathews, John A, Kara, Madina, Hughes, Katherine A, Kenyon, Christopher J, Walker, Brian R, Andrew, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104038/ https://www.ncbi.nlm.nih.gov/pubmed/24872577 http://dx.doi.org/10.1530/JOE-13-0563

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