Biosynthesis of polybrominated aromatic organic compounds by marine bacteria

Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention due to their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynth...

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Autores principales: Agarwal, Vinayak, El Gamal, Abrahim A., Yamanaka, Kazuya, Poth, Dennis, Kersten, Roland D., Schorn, Michelle, Allen, Eric E., Moore, Bradley S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104138/
https://www.ncbi.nlm.nih.gov/pubmed/24974229
http://dx.doi.org/10.1038/nchembio.1564
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author Agarwal, Vinayak
El Gamal, Abrahim A.
Yamanaka, Kazuya
Poth, Dennis
Kersten, Roland D.
Schorn, Michelle
Allen, Eric E.
Moore, Bradley S.
author_facet Agarwal, Vinayak
El Gamal, Abrahim A.
Yamanaka, Kazuya
Poth, Dennis
Kersten, Roland D.
Schorn, Michelle
Allen, Eric E.
Moore, Bradley S.
author_sort Agarwal, Vinayak
collection PubMed
description Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention due to their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota. We provide biochemical evidence of marine brominase enzymes revealing decarboxylative-halogenation enzymology previously unknown among halogenating enzymes. Biosynthetic motifs discovered in our study were used to mine sequence databases to discover unrealized marine bacterial producers of organobromine compounds.
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spelling pubmed-41041382015-02-01 Biosynthesis of polybrominated aromatic organic compounds by marine bacteria Agarwal, Vinayak El Gamal, Abrahim A. Yamanaka, Kazuya Poth, Dennis Kersten, Roland D. Schorn, Michelle Allen, Eric E. Moore, Bradley S. Nat Chem Biol Article Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention due to their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota. We provide biochemical evidence of marine brominase enzymes revealing decarboxylative-halogenation enzymology previously unknown among halogenating enzymes. Biosynthetic motifs discovered in our study were used to mine sequence databases to discover unrealized marine bacterial producers of organobromine compounds. 2014-06-29 2014-08 /pmc/articles/PMC4104138/ /pubmed/24974229 http://dx.doi.org/10.1038/nchembio.1564 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Agarwal, Vinayak
El Gamal, Abrahim A.
Yamanaka, Kazuya
Poth, Dennis
Kersten, Roland D.
Schorn, Michelle
Allen, Eric E.
Moore, Bradley S.
Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
title Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
title_full Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
title_fullStr Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
title_full_unstemmed Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
title_short Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
title_sort biosynthesis of polybrominated aromatic organic compounds by marine bacteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104138/
https://www.ncbi.nlm.nih.gov/pubmed/24974229
http://dx.doi.org/10.1038/nchembio.1564
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