Biosynthesis of polybrominated aromatic organic compounds by marine bacteria
Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention due to their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynth...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104138/ https://www.ncbi.nlm.nih.gov/pubmed/24974229 http://dx.doi.org/10.1038/nchembio.1564 |
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author | Agarwal, Vinayak El Gamal, Abrahim A. Yamanaka, Kazuya Poth, Dennis Kersten, Roland D. Schorn, Michelle Allen, Eric E. Moore, Bradley S. |
author_facet | Agarwal, Vinayak El Gamal, Abrahim A. Yamanaka, Kazuya Poth, Dennis Kersten, Roland D. Schorn, Michelle Allen, Eric E. Moore, Bradley S. |
author_sort | Agarwal, Vinayak |
collection | PubMed |
description | Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention due to their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota. We provide biochemical evidence of marine brominase enzymes revealing decarboxylative-halogenation enzymology previously unknown among halogenating enzymes. Biosynthetic motifs discovered in our study were used to mine sequence databases to discover unrealized marine bacterial producers of organobromine compounds. |
format | Online Article Text |
id | pubmed-4104138 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-41041382015-02-01 Biosynthesis of polybrominated aromatic organic compounds by marine bacteria Agarwal, Vinayak El Gamal, Abrahim A. Yamanaka, Kazuya Poth, Dennis Kersten, Roland D. Schorn, Michelle Allen, Eric E. Moore, Bradley S. Nat Chem Biol Article Polybrominated diphenyl ethers (PBDEs) and polybrominated bipyrroles are natural products that bioaccumulate in the marine food chain. PBDEs have attracted widespread attention due to their persistence in the environment and potential toxicity to humans. However, the natural origins of PBDE biosynthesis are not known. Here we report marine bacteria as producers of PBDEs and establish a genetic and molecular foundation for their production that unifies paradigms for the elaboration of bromophenols and bromopyrroles abundant in marine biota. We provide biochemical evidence of marine brominase enzymes revealing decarboxylative-halogenation enzymology previously unknown among halogenating enzymes. Biosynthetic motifs discovered in our study were used to mine sequence databases to discover unrealized marine bacterial producers of organobromine compounds. 2014-06-29 2014-08 /pmc/articles/PMC4104138/ /pubmed/24974229 http://dx.doi.org/10.1038/nchembio.1564 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Agarwal, Vinayak El Gamal, Abrahim A. Yamanaka, Kazuya Poth, Dennis Kersten, Roland D. Schorn, Michelle Allen, Eric E. Moore, Bradley S. Biosynthesis of polybrominated aromatic organic compounds by marine bacteria |
title | Biosynthesis of polybrominated aromatic organic compounds by marine bacteria |
title_full | Biosynthesis of polybrominated aromatic organic compounds by marine bacteria |
title_fullStr | Biosynthesis of polybrominated aromatic organic compounds by marine bacteria |
title_full_unstemmed | Biosynthesis of polybrominated aromatic organic compounds by marine bacteria |
title_short | Biosynthesis of polybrominated aromatic organic compounds by marine bacteria |
title_sort | biosynthesis of polybrominated aromatic organic compounds by marine bacteria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104138/ https://www.ncbi.nlm.nih.gov/pubmed/24974229 http://dx.doi.org/10.1038/nchembio.1564 |
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