Estimating heritability of drug-induced liver injury from common variants and implications for future study designs

Recent genome-wide association studies identified certain human leukocyote antigen (HLA) alleles as the major risk factors of drug-induced liver injuries (DILI). While these alleles often cause large relative risk, their predictive values are quite low due to low prevalence of idiosyncratic DILI. Fi...

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Detalles Bibliográficos
Autores principales: Overby, Casey Lynnette, Hripcsak, George, Shen, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104390/
https://www.ncbi.nlm.nih.gov/pubmed/25042059
http://dx.doi.org/10.1038/srep05762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104390/
https://www.ncbi.nlm.nih.gov/pubmed/25042059
http://dx.doi.org/10.1038/srep05762

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