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Estimating heritability of drug-induced liver injury from common variants and implications for future study designs
Recent genome-wide association studies identified certain human leukocyote antigen (HLA) alleles as the major risk factors of drug-induced liver injuries (DILI). While these alleles often cause large relative risk, their predictive values are quite low due to low prevalence of idiosyncratic DILI. Fi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104390/ https://www.ncbi.nlm.nih.gov/pubmed/25042059 http://dx.doi.org/10.1038/srep05762 |