Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor

The integral membrane protein LIMP-2 has been a paradigm for mannose 6-phosphate receptor (MPR) independent lysosomal targeting, binding to β-glucocerebrosidase (β-GCase) and directing it to the lysosome, before dissociating in the late-endosomal/lysosomal compartments. Here we report structural res...

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Detalles Bibliográficos
Autores principales: Zhao, Yuguang, Ren, Jingshan, Padilla-Parra, Sergi, Fry, Elizabeth E., Stuart, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104448/
https://www.ncbi.nlm.nih.gov/pubmed/25027712
http://dx.doi.org/10.1038/ncomms5321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104448/
https://www.ncbi.nlm.nih.gov/pubmed/25027712
http://dx.doi.org/10.1038/ncomms5321

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