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Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor

The integral membrane protein LIMP-2 has been a paradigm for mannose 6-phosphate receptor (MPR) independent lysosomal targeting, binding to β-glucocerebrosidase (β-GCase) and directing it to the lysosome, before dissociating in the late-endosomal/lysosomal compartments. Here we report structural res...

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Detalles Bibliográficos
Autores principales:	Zhao, Yuguang, Ren, Jingshan, Padilla-Parra, Sergi, Fry, Elizabeth E., Stuart, David I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104448/ https://www.ncbi.nlm.nih.gov/pubmed/25027712 http://dx.doi.org/10.1038/ncomms5321

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