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Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

The role of remote astrocyte (AC) reaction to central or peripheral axonal insult is not clearly understood. Here we use a transgenic approach to compare the direct influence of normal with diminished AC reactivity on neuronal integrity and synapse recovery following extracranial facial nerve transe...

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Detalles Bibliográficos
Autores principales: Tyzack, Giulia E., Sitnikov, Sergey, Barson, Daniel, Adams-Carr, Kerala L., Lau, Nike K., Kwok, Jessica C., Zhao, Chao, Franklin, Robin J. M., Karadottir, Ragnhildur T., Fawcett, James W., Lakatos, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104454/
https://www.ncbi.nlm.nih.gov/pubmed/25014177
http://dx.doi.org/10.1038/ncomms5294