Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

Rho GTPases play a key role in the regulation of multiple essential cellular processes, including actin dynamics, gene transcription and cell cycle progression. Aberrant activation of Rac1, a member of Rho family of small GTPases, is associated with tumorigenesis, cancer progression, invasion and me...

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Detalles Bibliográficos
Autores principales: Cardama, Georgina A, Comin, Maria J, Hornos, Leandro, Gonzalez, Nazareno, Defelipe, Lucas, Turjanski, Adrian G, Alonso, Daniel F, Gomez, Daniel E, Menna, Pablo Lorenzano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104455/
https://www.ncbi.nlm.nih.gov/pubmed/24066799
http://dx.doi.org/10.2174/18715206113136660334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104455/
https://www.ncbi.nlm.nih.gov/pubmed/24066799
http://dx.doi.org/10.2174/18715206113136660334

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