Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked

Prions are lethal infectious agents thought to consist of multi-chain forms (PrP(Sc)) of misfolded cellular prion protein (PrP(C)). Prion propagation proceeds in two distinct mechanistic phases: an exponential phase 1, which rapidly reaches a fixed level of infectivity irrespective of PrP(C) express...

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Detalles Bibliográficos
Autores principales: Sandberg, Malin K., Al-Doujaily, Huda, Sharps, Bernadette, De Oliveira, Michael Wiggins, Schmidt, Christian, Richard-Londt, Angela, Lyall, Sarah, Linehan, Jacqueline M., Brandner, Sebastian, Wadsworth, Jonathan D. F., Clarke, Anthony R., Collinge, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104459/
https://www.ncbi.nlm.nih.gov/pubmed/25005024
http://dx.doi.org/10.1038/ncomms5347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104459/
https://www.ncbi.nlm.nih.gov/pubmed/25005024
http://dx.doi.org/10.1038/ncomms5347

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