Cargando…

HOXA10 is associated with temozolomide resistance through regulation of the homologous recombinant DNA repair pathway in glioblastoma cell lines

Temozolomide resistance is associated with multiple DNA repair pathways. We investigated homeobox (HOX) genes for their role in temozolomide resistance, focusing on the homologous recombination (HR) pathway, and we tested their therapeutic implications in conjunction with O(6)-methylguanine DNA meth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Jin Wook, Kim, Ji Young, Kim, Ja Eun, Kim, Seung-Ki, Chung, Hyun-Tai, Park, Chul-Kee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104759/ https://www.ncbi.nlm.nih.gov/pubmed/25061500

Ejemplares similares

ZSTK474 Sensitizes Glioblastoma to Temozolomide by Blocking Homologous Recombination Repair
por: Jiao, Wenhui, et al.
Publicado: (2022)

Underexpression of HOXA11 Is Associated with Treatment Resistance and Poor Prognosis in Glioblastoma
por: Se, Young-Bem, et al.
Publicado: (2017)

Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence
por: Berte, Nancy, et al.
Publicado: (2016)

A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide
por: Pojo, Marta, et al.
Publicado: (2015)

Concurrent Chemoradiotherapy with Temozolomide Followed by Adjuvant Temozolomide for Newly Diagnosed Glioblastoma Patients: A Retrospective Multicenter Observation Study in Korea
por: Kim, Byung Sup, et al.
Publicado: (2017)

Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2
por: Zhang, Xin, et al.
Publicado: (2022)

Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination
por: Reich, Thomas R., et al.
Publicado: (2021)

Metformin treatment reduces temozolomide resistance of glioblastoma cells
por: Yang, Seung Ho, et al.
Publicado: (2016)

Prediction of Response to Concurrent Chemoradiotherapy with Temozolomide in Glioblastoma: Application of Immediate Post-Operative Dynamic Susceptibility Contrast and Diffusion-Weighted MR Imaging
por: Lee, Eun Kyoung, et al.
Publicado: (2015)

Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma
por: Yun, Eun-Jin, et al.
Publicado: (2020)

Integrin αVβ3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair
por: Christmann, Markus, et al.
Publicado: (2016)

HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas
por: Jäger, Daniela, et al.
Publicado: (2017)

TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair
por: Hariharasudhan, Gurusamy, et al.
Publicado: (2022)

Oncogenic Impact of TONSL, a Homologous Recombination Repair Protein at the Replication Fork, in Cancer Stem Cells
por: Lee, Hani, et al.
Publicado: (2023)

BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair
por: Zhang, Shaolu, et al.
Publicado: (2021)

A long-range interactive DNA methylation marker panel for the promoters of HOXA9 and HOXA10 predicts survival in breast cancer patients
por: Park, Seong-Min, et al.
Publicado: (2017)

Gossypol Suppresses Growth of Temozolomide-Resistant Glioblastoma Tumor Spheres
por: Kim, Hee Yeon, et al.
Publicado: (2019)

Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma
por: Choi, Min Chul, et al.
Publicado: (2020)

Validation of the Effectiveness and Safety of Temozolomide during and after Radiotherapy for Newly Diagnosed Glioblastomas: 10-year Experience of a Single Institution
por: Joo, Jin-Deok, et al.
Publicado: (2015)

Association between survival and levetiracetam use in glioblastoma patients treated with temozolomide chemoradiotherapy
por: Roh, Tae Hoon, et al.
Publicado: (2020)

Continuous Low-Dose Temozolomide Chemotherapy and Microvessel Density in Recurrent Glioblastoma
por: Woo, Jong-Yun, et al.
Publicado: (2015)

Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines
por: Nagel, Stefan, et al.
Publicado: (2010)

+HOXA10-AS Promotes Malignant Phenotypes of Gastric Cancer via Upregulating HOXA10
por: Cao, Fengyu, et al.
Publicado: (2022)

LncRNA HOXA-AS2 Promotes Temozolomide Resistance in Glioblastoma by Regulated miR-302a-3p/IGF1 Axis
por: Lin, Ligang, et al.
Publicado: (2022)

Characterization of Temozolomide Resistance Using a Novel Acquired Resistance Model in Glioblastoma Cell Lines
por: Zhu, Yuan, et al.
Publicado: (2022)

Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres
por: Oh, Hyeong-Cheol, et al.
Publicado: (2020)

Repurposing Penfluridol in Combination with Temozolomide for the Treatment of Glioblastoma
por: Kim, Hyungsin, et al.
Publicado: (2019)

Prognosis Prediction of Measurable Enhancing Lesion after Completion of Standard Concomitant Chemoradiotherapy and Adjuvant Temozolomide in Glioblastoma Patients: Application of Dynamic Susceptibility Contrast Perfusion and Diffusion-Weighted Imaging
por: Kim, Jae Hyun, et al.
Publicado: (2014)

Retracted: +HOXA10-AS Promotes Malignant Phenotypes of Gastric Cancer via Upregulating HOXA10
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Revealing the epigenetic effect of temozolomide on glioblastoma cell lines in therapeutic conditions
por: Belter, Agnieszka, et al.
Publicado: (2020)

Classification of High-Grade Serous Ovarian Carcinoma by Epithelial-to-Mesenchymal Transition Signature and Homologous Recombination Repair Genes
por: Sohn, Min-Hwan, et al.
Publicado: (2021)

Tumor Microenvironment and Genes Affecting the Prognosis of Temozolomide-Treated Glioblastoma
por: Jang, Yena, et al.
Publicado: (2023)

Temozolomide Salvage Chemotherapy for Recurrent Anaplastic Oligodendroglioma and Oligo-Astrocytoma
por: Gwak, Ho-Shin, et al.
Publicado: (2013)

Repair of 3-methyladenine and abasic sites by base excision repair mediates glioblastoma resistance to temozolomide
por: Bobola, Michael S., et al.
Publicado: (2012)

Temozolomide resistance in glioblastoma multiforme
por: Lee, Sang Y.
Publicado: (2016)

ER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosis
por: Weatherbee, Jessica L., et al.
Publicado: (2016)

XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair
por: Dai, Weimin, et al.
Publicado: (2022)

Patient-derived glioblastoma cell lines with conserved genome profiles of the original tissue
por: Kim, Soon-Chan, et al.
Publicado: (2023)

Autophagy enhancement contributes to the synergistic effect of vitamin D in temozolomide-based glioblastoma chemotherapy
por: BAK, DONG-HO, et al.
Publicado: (2016)

Genome-wide Transcriptome Profiling of Homologous Recombination DNA Repair
por: Peng, Guang, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_taojij2je2kqaf7at9raech2j1