Small Molecule Inhibition of SAMHD1 dNTPase by Tetramer Destabilization

[Image: see text] SAMHD1 is a GTP-activated nonspecific dNTP triphosphohydrolase that depletes dNTP pools in resting CD4+ T cells and macrophages and effectively restricts infection by HIV-1. We have designed a nonsubstrate dUTP analogue with a methylene bridge connecting the α phosphate and 5′ carb...

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Detalles Bibliográficos
Autores principales: Seamon, Kyle J., Hansen, Erik C., Kadina, Anastasia P., Kashemirov, Boris A., McKenna, Charles E., Bumpus, Namandjé N., Stivers, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105058/
https://www.ncbi.nlm.nih.gov/pubmed/24983818
http://dx.doi.org/10.1021/ja5035717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105058/
https://www.ncbi.nlm.nih.gov/pubmed/24983818
http://dx.doi.org/10.1021/ja5035717

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