A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin

[Image: see text] The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry pre...

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Autores principales: Liao, Longyan, Liu, Jenny, Dreaden, Erik C., Morton, Stephen W., Shopsowitz, Kevin E., Hammond, Paula T., Johnson, Jeremiah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105175/
https://www.ncbi.nlm.nih.gov/pubmed/24724706
http://dx.doi.org/10.1021/ja502011g
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author Liao, Longyan
Liu, Jenny
Dreaden, Erik C.
Morton, Stephen W.
Shopsowitz, Kevin E.
Hammond, Paula T.
Johnson, Jeremiah A.
author_facet Liao, Longyan
Liu, Jenny
Dreaden, Erik C.
Morton, Stephen W.
Shopsowitz, Kevin E.
Hammond, Paula T.
Johnson, Jeremiah A.
author_sort Liao, Longyan
collection PubMed
description [Image: see text] The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry precise molar ratios of doxorubicin, camptothecin, and cisplatin. To our knowledge, this work provides the first example of orthogonally triggered release of three drugs from single NPs. The highly convergent synthetic approach opens the door to new NP-based combination therapies for cancer.
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spelling pubmed-41051752015-04-11 A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin Liao, Longyan Liu, Jenny Dreaden, Erik C. Morton, Stephen W. Shopsowitz, Kevin E. Hammond, Paula T. Johnson, Jeremiah A. J Am Chem Soc [Image: see text] The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry precise molar ratios of doxorubicin, camptothecin, and cisplatin. To our knowledge, this work provides the first example of orthogonally triggered release of three drugs from single NPs. The highly convergent synthetic approach opens the door to new NP-based combination therapies for cancer. American Chemical Society 2014-04-11 2014-04-23 /pmc/articles/PMC4105175/ /pubmed/24724706 http://dx.doi.org/10.1021/ja502011g Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Liao, Longyan
Liu, Jenny
Dreaden, Erik C.
Morton, Stephen W.
Shopsowitz, Kevin E.
Hammond, Paula T.
Johnson, Jeremiah A.
A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin
title A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin
title_full A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin
title_fullStr A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin
title_full_unstemmed A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin
title_short A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin
title_sort convergent synthetic platform for single-nanoparticle combination cancer therapy: ratiometric loading and controlled release of cisplatin, doxorubicin, and camptothecin
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105175/
https://www.ncbi.nlm.nih.gov/pubmed/24724706
http://dx.doi.org/10.1021/ja502011g
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