Optimal Aggregation of FcεRI with a Structurally Defined Trivalent Ligand Overrides Negative Regulation Driven by Phosphatases

[Image: see text] To investigate why responses of mast cells to antigen-induced IgE receptor (FcεRI) aggregation depend nonlinearly on antigen dose, we characterized a new artificial ligand, DF3, through complementary modeling and experimentation. This ligand is a stable trimer of peptides derived f...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahajan, Avanika, Barua, Dipak, Cutler, Patrick, Lidke, Diane S., Espinoza, Flor A., Pehlke, Carolyn, Grattan, Rachel, Kawakami, Yuko, Tung, Chang-Shung, Bradbury, Andrew R. M., Hlavacek, William S., Wilson, Bridget S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105180/
https://www.ncbi.nlm.nih.gov/pubmed/24784318
http://dx.doi.org/10.1021/cb500134t

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105180/
https://www.ncbi.nlm.nih.gov/pubmed/24784318
http://dx.doi.org/10.1021/cb500134t

Ejemplares similares