Insights into the evolution and domain structure of ataxin-2 proteins across eukaryotes

BACKGROUND: Ataxin-2 is an evolutionarily conserved protein first identified in humans as responsible for spinocerebellar ataxia type 2 (SCA2). The molecular basis of SCA2 is the expansion of a polyglutamine tract in Ataxin-2, encoding a Lsm domain that may bind RNA and a PAM2 motif that enables int...

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Detalles Bibliográficos
Autores principales: Jiménez-López, Domingo, Guzmán, Plinio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105795/
https://www.ncbi.nlm.nih.gov/pubmed/25027299
http://dx.doi.org/10.1186/1756-0500-7-453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105795/
https://www.ncbi.nlm.nih.gov/pubmed/25027299
http://dx.doi.org/10.1186/1756-0500-7-453

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