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Insights into the evolution and domain structure of ataxin-2 proteins across eukaryotes
BACKGROUND: Ataxin-2 is an evolutionarily conserved protein first identified in humans as responsible for spinocerebellar ataxia type 2 (SCA2). The molecular basis of SCA2 is the expansion of a polyglutamine tract in Ataxin-2, encoding a Lsm domain that may bind RNA and a PAM2 motif that enables int...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105795/ https://www.ncbi.nlm.nih.gov/pubmed/25027299 http://dx.doi.org/10.1186/1756-0500-7-453 |