The Self-Limiting Dynamics of TGF-β Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation

The TGF-β/Smad signaling system decreases its activity through strong negative regulation. Several molecular mechanisms of negative regulation have been published, but the relative impact of each mechanism on the overall system is unknown. In this work, we used computational and experimental methods...

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Detalles Bibliográficos
Autores principales: Wang, Junjie, Tucker-Kellogg, Lisa, Ng, Inn Chuan, Jia, Ruirui, Thiagarajan, P. S., White, Jacob K., Yu, Hanry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105941/
https://www.ncbi.nlm.nih.gov/pubmed/24901250
http://dx.doi.org/10.1371/journal.pcbi.1003573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105941/
https://www.ncbi.nlm.nih.gov/pubmed/24901250
http://dx.doi.org/10.1371/journal.pcbi.1003573

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