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BRAF-targeted therapy alters the functions of intratumoral CD4(+) T cells to inhibit melanoma progression
The establishment of an immunosuppressive tumor microenvironment is a hallmark feature driving cancer cell evasion of immunosurveillance. In a murine melanoma model, we recently demonstrated that decreased intratumoral CD4(+) T-cell expression of CD40L and interferon γ (IFNγ) is critical to maintain...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106160/ https://www.ncbi.nlm.nih.gov/pubmed/25083331 http://dx.doi.org/10.4161/onci.29126 |