Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have distinct clinical features but a common pathology—cytoplasmic inclusions rich in TDP43. Rare TDP43 mutations cause ALS or FTD, but abnormal TDP43 levels and localization may cause disease even if TDP43 lacks a mutation. Here...

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Detalles Bibliográficos
Autores principales: Barmada, Sami J., Serio, Andrea, Arjun, Arpana, Bilican, Bilada, Daub, Aaron, Ando, D. Michael, Tsvetkov, Andrey, Pleiss, Michael, Li, Xingli, Peisach, Daniel, Shaw, Christopher, Chandran, Siddharthan, Finkbeiner, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106236/
https://www.ncbi.nlm.nih.gov/pubmed/24974230
http://dx.doi.org/10.1038/nchembio.1563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106236/
https://www.ncbi.nlm.nih.gov/pubmed/24974230
http://dx.doi.org/10.1038/nchembio.1563

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