Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

Metabolic remodeling is now widely regarded as a hallmark of cancer, but it is not clear whether individual metabolic strategies are frequently exploited by many tumours. Here we compare messenger RNA profiles of 1,454 metabolic enzymes across 1,981 tumours spanning 19 cancer types to identify enzym...

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Detalles Bibliográficos
Autores principales: Nilsson, Roland, Jain, Mohit, Madhusudhan, Nikhil, Sheppard, Nina Gustafsson, Strittmatter, Laura, Kampf, Caroline, Huang, Jenny, Asplund, Anna, Mootha, Vamsi K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106362/
https://www.ncbi.nlm.nih.gov/pubmed/24451681
http://dx.doi.org/10.1038/ncomms4128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106362/
https://www.ncbi.nlm.nih.gov/pubmed/24451681
http://dx.doi.org/10.1038/ncomms4128

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