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Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles

In the mammalian ovary a small number of follicles are steadily recruited from the quiescent pool to undergo development. Follicle loss, maintenance and growth are strictly controlled by complex molecular interactions including the phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt) signalling p...

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Detalles Bibliográficos
Autores principales: McLaughlin, Marie, Kinnell, Hazel L., Anderson, Richard A., Telfer, Evelyn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106636/
https://www.ncbi.nlm.nih.gov/pubmed/24830779
http://dx.doi.org/10.1093/molehr/gau037