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FRET-Assisted Determination of CLN3 Membrane Topology

Juvenile neuronal ceroid lipofuscinosis (JNCL) is caused by mutations in the CLN3 gene, which encodes for a putative lysosomal transmembrane protein with thus far undescribed structure and function. Here we investigate the membrane topology of human CLN3 protein with a combination of advanced molecu...

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Detalles Bibliográficos
Autores principales:	Ratajczak, Ewa, Petcherski, Anton, Ramos-Moreno, Juliana, Ruonala, Mika O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106830/ https://www.ncbi.nlm.nih.gov/pubmed/25051496 http://dx.doi.org/10.1371/journal.pone.0102593

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