FTY720 Induces Apoptosis of M2 Subtype Acute Myeloid Leukemia Cells by Targeting Sphingolipid Metabolism and Increasing Endogenous Ceramide Levels

The M2 subtype Acute Myeloid Leukemia (AML-M2) with t(8;21) represents an unmet challenge because of poor clinical outcomes in a sizable portion of patients. In this study,we report that FTY720 (Fingolimod), a sphingosine analogue and an FDA approved drug for treating of multiple sclerosis, shows an...

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Detalles Bibliográficos
Autores principales: Chen, Limin, Luo, Liu-Fei, Lu, Junyan, Li, Lianchun, Liu, Yuan-Fang, Wang, Jiang, Liu, Hong, Song, Heng, Jiang, Hualiang, Chen, Sai-Juan, Luo, Cheng, Li, Keqin Kathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106898/
https://www.ncbi.nlm.nih.gov/pubmed/25050888
http://dx.doi.org/10.1371/journal.pone.0103033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106898/
https://www.ncbi.nlm.nih.gov/pubmed/25050888
http://dx.doi.org/10.1371/journal.pone.0103033

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