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Animal versus human oral drug bioavailability: Do they correlate?

Oral bioavailability is a key consideration in development of drug products, and the use of preclinical species in predicting bioavailability in human has long been debated. In order to clarify whether any correlation between human and animal bioavailability exist, an extensive analysis of the publi...

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Detalles Bibliográficos
Autores principales: Musther, Helen, Olivares-Morales, Andrés, Hatley, Oliver J.D., Liu, Bo, Rostami Hodjegan, Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107270/
https://www.ncbi.nlm.nih.gov/pubmed/23988844
http://dx.doi.org/10.1016/j.ejps.2013.08.018