Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in Ca(V)2.1 knockin migraine mice

Familial hemiplegic migraine type 1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) calcium channels. In FHM1 knockin mice, excitatory neurotransmission at cortical pyramidal cell synapses is enhanced, but inhibitory neurotransmission...

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Detalles Bibliográficos
Autores principales: Vecchia, Dania, Tottene, Angelita, van den Maagdenberg, Arn M.J.M., Pietrobon, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107271/
https://www.ncbi.nlm.nih.gov/pubmed/24907493
http://dx.doi.org/10.1016/j.nbd.2014.05.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107271/
https://www.ncbi.nlm.nih.gov/pubmed/24907493
http://dx.doi.org/10.1016/j.nbd.2014.05.035

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