TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease

Aortic valve disease (AVD) is characterized by elastic fiber fragmentation (EFF), fibrosis and aberrant angiogenesis. Emilin1 is an elastin-binding glycoprotein that regulates elastogenesis and inhibits TGF-β signaling, but the role of Emilin1 in valve tissue is unknown. We tested the hypothesis tha...

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Detalles Bibliográficos
Autores principales: Munjal, Charu, Opoka, Amy M., Osinska, Hanna, James, Jeanne F., Bressan, Giorgio M., Hinton, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107327/
https://www.ncbi.nlm.nih.gov/pubmed/25056700
http://dx.doi.org/10.1242/dmm.015255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107327/
https://www.ncbi.nlm.nih.gov/pubmed/25056700
http://dx.doi.org/10.1242/dmm.015255

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