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Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption

Previous studies indicate that memantine, a low-affinity N-methyl-D-aspartate receptor antagonist, exerted acute protective effects against amyloid-β protein-induced neurotoxicity. In the present study, the chronic effects and mechanisms of memantine were investigated further using electrophysiologi...

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Autores principales: Li, Fushun, Chen, Xiaowei, Wang, Feiming, Xu, Shujun, Chang, Lan, Anwyl, Roger, Wang, Qinwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107499/
https://www.ncbi.nlm.nih.gov/pubmed/25206371
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.01.006
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author Li, Fushun
Chen, Xiaowei
Wang, Feiming
Xu, Shujun
Chang, Lan
Anwyl, Roger
Wang, Qinwen
author_facet Li, Fushun
Chen, Xiaowei
Wang, Feiming
Xu, Shujun
Chang, Lan
Anwyl, Roger
Wang, Qinwen
author_sort Li, Fushun
collection PubMed
description Previous studies indicate that memantine, a low-affinity N-methyl-D-aspartate receptor antagonist, exerted acute protective effects against amyloid-β protein-induced neurotoxicity. In the present study, the chronic effects and mechanisms of memantine were investigated further using electrophysiological methods. The results showed that 7-day intraperitoneal application of memantine, at doses of 5 mg/kg or 20 mg/kg, did not alter hippocampal long-term potentiation induction in rats, while 40 mg/kg memantine presented potent long-term potentiation inhibition. Then further in vitro studys were carried out in 5 mg/kg and 20 mg/kg memantine treated rats. We found that 20 mg/kg memantine attenuated the potent long-term potentiation inhibition caused by exposure to amyloid-β protein in the dentate gyrus in vitro. These findings are the first to demonstrate the antagonizing effect of long-term systematic treatment of memantine against amyloid-β protein triggered long-term potentiation inhibition to improve synaptic plasticity.
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spelling pubmed-41074992014-09-09 Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption Li, Fushun Chen, Xiaowei Wang, Feiming Xu, Shujun Chang, Lan Anwyl, Roger Wang, Qinwen Neural Regen Res Research and Report Article: Neurodegenerative Disease and Neural Regeneration Previous studies indicate that memantine, a low-affinity N-methyl-D-aspartate receptor antagonist, exerted acute protective effects against amyloid-β protein-induced neurotoxicity. In the present study, the chronic effects and mechanisms of memantine were investigated further using electrophysiological methods. The results showed that 7-day intraperitoneal application of memantine, at doses of 5 mg/kg or 20 mg/kg, did not alter hippocampal long-term potentiation induction in rats, while 40 mg/kg memantine presented potent long-term potentiation inhibition. Then further in vitro studys were carried out in 5 mg/kg and 20 mg/kg memantine treated rats. We found that 20 mg/kg memantine attenuated the potent long-term potentiation inhibition caused by exposure to amyloid-β protein in the dentate gyrus in vitro. These findings are the first to demonstrate the antagonizing effect of long-term systematic treatment of memantine against amyloid-β protein triggered long-term potentiation inhibition to improve synaptic plasticity. Medknow Publications & Media Pvt Ltd 2013-01-05 /pmc/articles/PMC4107499/ /pubmed/25206371 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.01.006 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Neurodegenerative Disease and Neural Regeneration
Li, Fushun
Chen, Xiaowei
Wang, Feiming
Xu, Shujun
Chang, Lan
Anwyl, Roger
Wang, Qinwen
Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption
title Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption
title_full Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption
title_fullStr Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption
title_full_unstemmed Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption
title_short Chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption
title_sort chronic pre-treatment with memantine prevents amyloid-beta protein-mediated long-term potentiation disruption
topic Research and Report Article: Neurodegenerative Disease and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107499/
https://www.ncbi.nlm.nih.gov/pubmed/25206371
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.01.006
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