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Combined use of ursodeoxycholic acid and bosentan prevents liver toxicity caused by endothelin receptor antagonist bosentan monotherapy: two case reports

INTRODUCTION: Pulmonary arterial hypertension is a fatal disease characterized by progressive remodeling of the pulmonary arteries and an increase in pulmonary vascular resistance. Up to 50% of patients with systemic sclerosis have pulmonary arterial hypertension, which significantly affects the pro...

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Detalles Bibliográficos
Autores principales: Ito, Tomoki, Ozaki, Yoshio, Son, Yonsu, Nishizawa, Tohru, Amuro, Hideki, Tanaka, Akihiro, Tamaki, Takeshi, Nomura, Shosaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107936/
https://www.ncbi.nlm.nih.gov/pubmed/25015229
http://dx.doi.org/10.1186/1752-1947-8-250