A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process

BACKGROUND: Targeting cancer cell metabolism is recognized as a promising arena for development of cancer chemotherapeutics. Moreover, redox metabolism is also systematically altered in tumor cells. Indeed, there is growing reason to believe that tumor-specific alteration of redox control of metabol...

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Detalles Bibliográficos
Autores principales: Stuart, Shawn D, Schauble, Alexandra, Gupta, Sunita, Kennedy, Adam D, Keppler, Brian R, Bingham, Paul M, Zachar, Zuzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108059/
https://www.ncbi.nlm.nih.gov/pubmed/24612826
http://dx.doi.org/10.1186/2049-3002-2-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108059/
https://www.ncbi.nlm.nih.gov/pubmed/24612826
http://dx.doi.org/10.1186/2049-3002-2-4

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