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A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process
BACKGROUND: Targeting cancer cell metabolism is recognized as a promising arena for development of cancer chemotherapeutics. Moreover, redox metabolism is also systematically altered in tumor cells. Indeed, there is growing reason to believe that tumor-specific alteration of redox control of metabol...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108059/ https://www.ncbi.nlm.nih.gov/pubmed/24612826 http://dx.doi.org/10.1186/2049-3002-2-4 |