Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

BACKGROUND: Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate in these cells has been linked to the tum...

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Detalles Bibliográficos
Autores principales: Zheng, Liang, MacKenzie, Elaine D, Karim, Saadia A, Hedley, Ann, Blyth, Karen, Kalna, Gabriela, Watson, David G, Szlosarek, Peter, Frezza, Christian, Gottlieb, Eyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108060/
https://www.ncbi.nlm.nih.gov/pubmed/24280230
http://dx.doi.org/10.1186/2049-3002-1-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108060/
https://www.ncbi.nlm.nih.gov/pubmed/24280230
http://dx.doi.org/10.1186/2049-3002-1-12

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