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Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

BACKGROUND: Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate in these cells has been linked to the tum...

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Detalles Bibliográficos
Autores principales:	Zheng, Liang, MacKenzie, Elaine D, Karim, Saadia A, Hedley, Ann, Blyth, Karen, Kalna, Gabriela, Watson, David G, Szlosarek, Peter, Frezza, Christian, Gottlieb, Eyal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108060/ https://www.ncbi.nlm.nih.gov/pubmed/24280230 http://dx.doi.org/10.1186/2049-3002-1-12

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