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Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2
BACKGROUND: The human ether-a-go-go-related gene potassium channel (hERG) has an unusual long turret, whose role in recognizing scorpion toxins remains controversial. Here, BmKKx2, the first specific blocker of hERG channel derived from scorpion Mesobuthus martensii, was identified and the turret ro...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108063/ https://www.ncbi.nlm.nih.gov/pubmed/24725272 http://dx.doi.org/10.1186/2045-3701-4-18 |