Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2

BACKGROUND: The human ether-a-go-go-related gene potassium channel (hERG) has an unusual long turret, whose role in recognizing scorpion toxins remains controversial. Here, BmKKx2, the first specific blocker of hERG channel derived from scorpion Mesobuthus martensii, was identified and the turret ro...

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Detalles Bibliográficos
Autores principales: Hu, You-Tian, Hu, Jun, Li, Tian, Wei, Jing-Jing, Feng, Jing, Du, Yi-Mei, Cao, Zhi-Jian, Li, Wen-Xin, Wu, Ying-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108063/
https://www.ncbi.nlm.nih.gov/pubmed/24725272
http://dx.doi.org/10.1186/2045-3701-4-18

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