Activation of Akt protects cancer cells from growth inhibition induced by PKM2 knockdown

BACKGROUND: PKM2 is an attractive target for cancer therapy, however, for many cancer cells, PKM2 knockdown only leads to a modest impairment of survival and proliferation. It is not known whether PKM2 knockdown rewires cell signaling pathways in these “PKM2 knockdown resistant” cells, and whether t...

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Detalles Bibliográficos
Autores principales: Qin, Xiaodong, Du, Yuping, Chen, Xing, Li, Wuyan, Zhang, Jinghong, Yang, Jinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108064/
https://www.ncbi.nlm.nih.gov/pubmed/24735734
http://dx.doi.org/10.1186/2045-3701-4-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108064/
https://www.ncbi.nlm.nih.gov/pubmed/24735734
http://dx.doi.org/10.1186/2045-3701-4-20

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