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Activation of Akt protects cancer cells from growth inhibition induced by PKM2 knockdown
BACKGROUND: PKM2 is an attractive target for cancer therapy, however, for many cancer cells, PKM2 knockdown only leads to a modest impairment of survival and proliferation. It is not known whether PKM2 knockdown rewires cell signaling pathways in these “PKM2 knockdown resistant” cells, and whether t...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108064/ https://www.ncbi.nlm.nih.gov/pubmed/24735734 http://dx.doi.org/10.1186/2045-3701-4-20 |