Cargando…

Fumagillin Prodrug Nanotherapy Suppresses Macrophage Inflammatory Response via Endothelial Nitric Oxide

[Image: see text] Antiangiogenesis has been extensively explored for the treatment of a variety of cancers and certain inflammatory processes. Fumagillin, a mycotoxin produced by Aspergillus fumigatus that binds methionine aminopeptidase 2 (MetAP-2), is a potent antiangiogenic agent. Native fumagill...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Hui-fang, Yan, Huimin, Hu, Ying, Springer, Luke E., Yang, Xiaoxia, Wickline, Samuel A., Pan, Dipanjan, Lanza, Gregory M., Pham, Christine T. N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108210/ https://www.ncbi.nlm.nih.gov/pubmed/24941020 http://dx.doi.org/10.1021/nn502372n

Ejemplares similares

α(ν)β(3)-targeted Copper Nanoparticles Incorporating an Sn 2 Lipase-Labile Fumagillin Prodrug for Photoacoustic Neovascular Imaging and Treatment
por: Zhang, Ruiying, et al.
Publicado: (2015)

Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery
por: Pan, Dipanjan, et al.
Publicado: (2016)

Nanotherapy delivery of c-myc inhibitor targets Protumor Macrophages and preserves Antitumor Macrophages in Breast Cancer
por: Esser, Alison K., et al.
Publicado: (2020)

Targeting NF-κB with Nanotherapy in a Mouse Model of Adult T-Cell Leukemia/Lymphoma
por: Rauch, Daniel A., et al.
Publicado: (2021)

Atherosclerosis endothelial activation quantification in vivo with fluorine magnetic resonance imaging and spectroscopy
por: Pan, Hua, et al.
Publicado: (2014)

Nosema ceranae Escapes Fumagillin Control in Honey Bees
por: Huang, Wei-Fone, et al.
Publicado: (2013)

Aspergillus fumigatus Fumagillin Contributes to Host Cell Damage
por: Guruceaga, Xabier, et al.
Publicado: (2021)

Anti-Angiogenesis Therapy in the Vx2 Rabbit Cancer Model with a Lipase-cleavable Sn 2 Taxane Phospholipid Prodrug using α(v)β(3)-Targeted Theranostic Nanoparticles
por: Pan, Dipanjan, et al.
Publicado: (2014)

Cellular Trafficking of Sn-2 Phosphatidylcholine Prodrugs Studied with Fluorescence Lifetime Imaging and Super-resolution Microscopy
por: Maji, Dolonchampa, et al.
Publicado: (2018)

Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin
por: Bukreyeva, Iryna, et al.
Publicado: (2017)

Effects of Mycotoxin Fumagillin, Mevastatin, Radicicol, and Wortmannin on Photosynthesis of Chlamydomonas reinhardtii
por: Shi, Jiale, et al.
Publicado: (2023)

Tumor Microenvironment Targeted Nanotherapy
por: Fernandes, Clara, et al.
Publicado: (2018)

Imaging-assisted anticancer nanotherapy
por: Dasgupta, Anshuman, et al.
Publicado: (2020)

Successful Treatment of Disseminated Anncaliia algerae Microsporidial Infection With Combination Fumagillin and Albendazole
por: Boileau, Mélissa, et al.
Publicado: (2016)

Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications
por: Guruceaga, Xabier, et al.
Publicado: (2019)

Ormeloxifene nanotherapy for cervical cancer treatment
por: Chauhan, Neeraj, et al.
Publicado: (2019)

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases
por: Li, Chen-Wen, et al.
Publicado: (2020)

A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus
por: Guruceaga, Xabier, et al.
Publicado: (2018)

Potential of Fumagillin and Agaricus blazei Mushroom Extract to Reduce Nosema ceranae in Honey Bees
por: Glavinic, Uros, et al.
Publicado: (2021)

Macrophage-mediated delivery of light activated nitric oxide prodrugs with spatial, temporal and concentration control
por: Evans, Michael A., et al.
Publicado: (2018)

Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy
por: Wang, Stephanie J., et al.
Publicado: (2020)

The Fumagillin Gene Cluster, an Example of Hundreds of Genes under veA Control in Aspergillus fumigatus
por: Dhingra, Sourabh, et al.
Publicado: (2013)

Fumagillin Attenuates Spinal Angiogenesis, Neuroinflammation, and Pain in Neuropathic Rats after Chronic Constriction Injury
por: Wen, Zhi-Hong, et al.
Publicado: (2021)

Molecular targets in arthritis and recent trends in nanotherapy
por: Roy, Kislay, et al.
Publicado: (2015)

Strategies on Nanodiagnostics and Nanotherapies of the Three Common Cancers
por: Leng, Fan, et al.
Publicado: (2018)

Prediction of Anti-cancer Nanotherapy Efficacy by Imaging
por: Miller, Miles A., et al.
Publicado: (2017)

Bioinspired and Biomimetic Nanotherapies for the Treatment of Infectious Diseases
por: Yang, Guoyu, et al.
Publicado: (2019)

Anti-angiogenic Nanotherapy Inhibits Airway Remodeling and Hyper-responsiveness of Dust Mite Triggered Asthma in the Brown Norway Rat
por: Lanza, Gregory M., et al.
Publicado: (2017)

Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats
por: Kass, Daniel J., et al.
Publicado: (2012)

Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway
por: Lin, Hsiao-Ching, et al.
Publicado: (2014)

In vitro study on aspects of molecular mechanisms underlying invasive aspergillosis caused by gliotoxin and fumagillin, alone and in combination
por: Gayathri, Loganathan, et al.
Publicado: (2020)

Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) for the Treatment of Unresectable and Metastatic Cancers
por: Liu, Yang, et al.
Publicado: (2017)

Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies
por: Ediriwickrema, Asiri, et al.
Publicado: (2015)

Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease
por: Zhao, Jiulong, et al.
Publicado: (2019)

Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy
por: Pérez-Medina, Carlos, et al.
Publicado: (2016)

Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment
por: Wang, Pingping, et al.
Publicado: (2020)

Transferrin: Biology and Use in Receptor-Targeted Nanotherapy of Gliomas
por: Koneru, Tejaswi, et al.
Publicado: (2021)

Peptides to Overcome the Limitations of Current Anticancer and Antimicrobial Nanotherapies
por: Del Genio, Valentina, et al.
Publicado: (2022)

Editorial for Special Issue “Cancer Treatment via Nanotherapy”
por: Wang, Lisheng
Publicado: (2023)

Designing Superoxide-Generating Quantum Dots for Selective Light-Activated Nanotherapy
por: Goodman, Samuel M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lluviuihgct44hkev1vsuvqqa2