Multiple E-Boxes in the Distal Promoter of the Rat Pyruvate Carboxylase Gene Function as a Glucose-Responsive Element

Pyruvate carboxylase (PC) is an anaplerotic enzyme that regulates glucose-induced insulin secretion in pancreatic islets. Dysregulation of its expression is associated with type 2 diabetes. Herein we describe the molecular mechanism underlying the glucose-mediated transcriptional regulation of the P...

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Detalles Bibliográficos
Autores principales: Wutthisathapornchai, Apilak, Vongpipatana, Tuangtong, Muangsawat, Sureeporn, Boonsaen, Thirajit, MacDonald, Michael J., Jitrapakdee, Sarawut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108332/
https://www.ncbi.nlm.nih.gov/pubmed/25054881
http://dx.doi.org/10.1371/journal.pone.0102730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108332/
https://www.ncbi.nlm.nih.gov/pubmed/25054881
http://dx.doi.org/10.1371/journal.pone.0102730

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