Cargando…

PIK3CA Gene Mutations and Overexpression: Implications for Prognostic Biomarker and Therapeutic Target in Chinese Esophageal Squamous Cell Carcinoma

AIMS: To evaluate PIK3CA gene mutations and PIK3CA expression status in Chinese esophageal squamous cell carcinoma (ESCC) patients, and their correlation with clinicopathological characteristics and clinical outcomes. METHODS: Direct sequencing was applied to investigate mutations in exons 9 and 20...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lin, Shan, Ling, Zhang, Shaokai, Ying, Jianming, Xue, Liyan, Yuan, Yanling, Xie, Yongqiang, Lu, Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108430/ https://www.ncbi.nlm.nih.gov/pubmed/25054828 http://dx.doi.org/10.1371/journal.pone.0103021

Ejemplares similares

PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma
por: Liu, Shi-Yuan, et al.
Publicado: (2017)

Prognostic implications of PIK3CA amplification in curatively resected liposarcoma
por: Kim, Joo Hoon, et al.
Publicado: (2016)

Diagnostic application of PIK3CA mutation analysis in Chinese esophageal cancer patients
por: Ming, Zizhen, et al.
Publicado: (2014)

Any Role of PIK3CA and PTEN Biomarkers in the Prognosis in Oral Squamous Cell Carcinoma?
por: Starzyńska, Anna, et al.
Publicado: (2020)

Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous cell carcinoma
por: IIJIMA, YOSHIHITO, et al.
Publicado: (2014)

Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
por: Chen, Li, et al.
Publicado: (2018)

PIK3CA amplification is associated with poor prognosis among patients with curatively resected esophageal squamous cell carcinoma
por: Kim, Hyo Song, et al.
Publicado: (2016)

Concordance between PIK3CA mutations in endoscopic biopsy and surgically resected specimens of esophageal squamous cell carcinoma
por: Hatogai, Ken, et al.
Publicado: (2017)

Prognostic value of the PIK3CA, AKT, and PTEN mutations in oral squamous cell carcinoma: literature review
por: Starzyńska, Anna, et al.
Publicado: (2020)

HER2 expression and relevant clinicopathological features in esophageal squamous cell carcinoma in a Chinese population
por: Rong, Lulu, et al.
Publicado: (2020)

Prevalence and Prognostic Role of PIK3CA/AKT1 Mutations in Chinese Breast Cancer Patients
por: Deng, Ling, et al.
Publicado: (2019)

Genome wide copy number analyses of superficial esophageal squamous cell carcinoma with and without metastasis
por: Wang, Pengjiao, et al.
Publicado: (2016)

Overexpression of OLC1 Promotes Tumorigenesis of Human Esophageal Squamous Cell Carcinoma
por: Li, Xiao, et al.
Publicado: (2014)

PD-L1 expression and its clinicopathological correlation in advanced esophageal squamous cell carcinoma in a Chinese population
por: Rong, Lulu, et al.
Publicado: (2019)

Mutational Characterization and Potential Prognostic Biomarkers of Chinese Patients with Esophageal Squamous Cell Carcinoma
por: Zhang, Nan, et al.
Publicado: (2020)

The prognostic value of EGFR overexpression and amplification in Esophageal squamous cell Carcinoma
por: Jiang, Dongxian, et al.
Publicado: (2015)

PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome
por: Munari, Fernanda Franco, et al.
Publicado: (2018)

Carcinogenesis of PIK3CA
por: German, Sidra, et al.
Publicado: (2013)

The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China
por: Wu, Haibo, et al.
Publicado: (2019)

Prognostic significance of lymphovascular invasion in patients with pT1b esophageal squamous cell carcinoma
por: Liu, Linxiu, et al.
Publicado: (2023)

Mutually exclusive mutations in NOTCH1 and PIK3CA associated with clinical prognosis and chemotherapy responses of esophageal squamous cell carcinoma in China
por: Song, Bin, et al.
Publicado: (2015)

KRAS, BRAF and PIK3CA Status in Squamous Cell Anal Carcinoma (SCAC)
por: Casadei Gardini, Andrea, et al.
Publicado: (2014)

SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma
por: Ma, Ming-Chun, et al.
Publicado: (2018)

PIK3CA and KRAS Amplification in Esophageal Adenocarcinoma and their Impact on the Inflammatory Tumor Microenvironment and Prognosis
por: Essakly, Ahlem, et al.
Publicado: (2019)

Mutation status and prognostic values of KRAS, NRAS, BRAF and PIK3CA in 353 Chinese colorectal cancer patients
por: Guo, Fang, et al.
Publicado: (2018)

The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer
por: Eklöf, V, et al.
Publicado: (2013)

PIK3CA in Colorectal Cancer
por: Cathomas, Gieri
Publicado: (2014)

RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma
por: Yu, Ning, et al.
Publicado: (2018)

Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma
por: Lee, Hong Kyu, et al.
Publicado: (2020)

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma
por: Chiosea, Simion I, et al.
Publicado: (2013)

Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance
por: Zainal, Nur Syafinaz, et al.
Publicado: (2019)

PIK3CA mutations define favorable prognostic biomarkers in operable breast cancer: a systematic review and meta-analysis
por: Liu, Yi-Rong, et al.
Publicado: (2014)

Mutation and prognostic analyses of PIK3CA in patients with completely resected lung adenocarcinoma
por: Song, Zhengbo, et al.
Publicado: (2016)

Mutation patterns and prognostic analysis of BRAF/KRAS/PIK3CA in colorectal cancer
por: Wang, Chengfeng, et al.
Publicado: (2022)

PIK3CA mutation analysis in Chinese patients with surgically resected cervical cancer
por: Xiang, Libing, et al.
Publicado: (2015)

Clinical-Pathologic Analysis of Breast Cancer With PIK3CA Mutations in Chinese Women
por: Lian, Jing, et al.
Publicado: (2020)

Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population
por: Huang, Qingfeng, et al.
Publicado: (2022)

Overexpression of the DEC1 Protein Induces Senescence In Vitro and Is Related to Better Survival in Esophageal Squamous Cell Carcinoma
por: Xu, Qing, et al.
Publicado: (2012)

PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression
por: Shah, Vandna, et al.
Publicado: (2017)

Prevalence and characteristics of PIK3CA mutation in mismatch repair-deficient colorectal cancer
por: Li, Weihua, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g2lhkve59n28898t0fd28qq90l